Academia

ITCC is an academic network bringing together all the required knowledge and know-how for the development of new treatments for children with cancer. With over 55 trials run in its extensive network of 62 clinical trial centers, ITCC has a proven track record of over 20 years of bringing treatment innovation to patients.

What can ITCC do for you?

ITCC is an open and highly collaborative network of researchers and hospitals with extensive experience in paediatric oncology. The network frequently partners with international disease specific treatment groups, academic trial sponsors, researchers and both small and large pharma to cooperatively strive towards developing new trial ideas into feasible early phase clinical trials. With a clinical trial sponsors committee as well as focused solid tumor, hematology and brain tumor scientific committees, ITCC offers expertise across the board covering all aspects of paediatric oncology drug development. Since 2021 to date, ITCC has evaluated over 35 trial proposals advising on all aspects ranging from molecular mechanism of action, treatment strategy, target population and organizational aspects to optimize the recruitment strategy.

ITCC investigators, if you have an early phase trial idea or are considering developing one, do not hesitate to get in touch with ITCC at the earliest opportunity!


ITCC Publication Track Records

As an academic network, ITCC has contributed to an extensive number of publications on pediatric oncology drug development, trial results and organizational aspects of trial conduct. In this page you can find the non-trial specific publications. The trial related papers will be available soon in the ITCC Clinical Trials Portfolio.

2021
International consensus on minimum preclinical testing requirements for the development of innovative therapies for children and adolescents with cancer.
Vassal, Gilles, et al.
Molecular cancer therapeutics 20.8: 1462-1468
2018
Outcome of children and adolescents with central nervous system tumors in phase I trials
Fernando Carceller, Francisco Bautista, Irene Jiménez, Raquel Hladun-Álvaro, Cécile Giraud, Luca Bergamaschi, Madhumita Dandapani, Isabelle Aerts, François Doz, Didier Frappaz, Michela Casanova, Bruce Morland, Darren R. Hargrave, Gilles Vassal, Andrew D. J. Pearson, Birgit Geoerger, Lucas Moreno & Lynley V. Marshall
Journal of Neuro-Oncology volume 137, pages 83–92
10-year report on the European Paediatric Regulation and its impact on new drugs for children's cancers
Andrew DJ Pearson Delphine Heenen Pamela R Kearns Anne Goeres Lynley V Marshall Patricia Blanc Gilles Vassal
DOI
2017
Accelerating drug development for neuroblastoma-new drug development strategy: an innovative therapies for children with cancer, European network for cancer research in children and adolescents and international society of paediatric oncology Europe neuroblastoma project.
Moreno, Lucas, et al.
Expert opinion on drug discovery 12.8: 801-811
Early phase clinical trials of anticancer agents in children and adolescents — an ITCC perspective
Lucas Moreno, Andrew D. J. Pearson, Xavier Paoletti, Irene Jimenez, Birgit Geoerger, Pamela R. Kearns, C. Michel Zwaan, Francois Doz, Andre Baruchel, Josef Vormoor, Michela Casanova, Stefan M. Pfister, Bruce Morland & Gilles Vassal on behalf of the Innovative Therapies for Children with Cancer (ITCC) Consortium
Nature Reviews Clinical Oncology volume 14, pages 497–507
2016
Prognostic factors of overall survival in children and adolescents enrolled in dose-finding trials in Europe: an innovative therapies for children with cancer study.
Carceller, Fernando, et al.
European Journal of Cancer 67: 130-140.
2012
Dose-finding designs in pediatric phase I clinical trials: comparison by simulations in a realistic timeline framework.
Doussau A, Asselain B, Le Deley MC, Geoerger B, Doz F, Vassal G, Paoletti X
Contemp Clin Trials. 2012 Jul;33(4):657-65. Epub 2012 Apr 13.
2010
The role of the 'innovative therapies for children with cancer' (ITCC) European consortium.
Zwaan CM, Kearns P, Caron H, Verschuur A, Riccardi R, Boos J, Doz F, Geoerger B, Morland B, Vassal G; 'innovative therapies for children with cancer' European consortium.
Cancer Treat Rev. 2010 Jun;36(4):328-34. Epub 2010 Mar 15. Review.

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